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Karen J. Hendershott, MD, FACS Karen J. Hendershott, MD, FACS

Karen J. Hendershott, MD, FACS

Breast Surgical Oncology

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To schedule an appointment call: 520-624-7445


Tucson - St. Mary’s

Tucson - St. Mary’s

1620 W. St. Mary’s Rd.
Tucson, AZ 85745
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Fax: 520-623-6145
Green Valley

Green Valley

1315 S. La Cañada Dr.
Green Valley, AZ 85622
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Fax: 520-623-6145
Tucson - Orange Grove

Tucson - Orange Grove

1845 W. Orange Grove Rd., Bldg. 2
Tucson, AZ 85704
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Fax: 520-623-6145

Education & Credentials

Medical School

University of Minnesota Medical School


University of Arizona


Surgical Oncology - Memorial Sloan Kettering Cancer Center | Breast Surgical Oncology - Maimonides Medical Center

Board Certification

General Surgery


  • American College of Surgery

In The Media


Karen J. Hendershott, MD, FACS is a fellowship-trained breast surgical oncologist who also completed a research fellowship at Memorial Sloan Kettering Cancer Center where she served as the chief academic fellow. She previously was an assistant professor of surgery and assistant program director at Cooper University Hospital where she was an award-winning educator. Dr. Hendershott has multiple publications in peer-reviewed journals and has presented at national surgical conferences. She currently serves as the medical director for the Breast Program at St. Mary’s Hospital. Board Certified and a Fellow with the American College of Surgery, she has over 10 years of experience specializing in the care of breast patients.

Dr. Hendershott specializes in the surgical management of genetic, familial, and triple-negative breast cancer. She has sub-specialty training in oncoplastic techniques to maximize cosmetic outcomes as well as partial breast radiation therapy, an advanced minimally invasive treatment option. In addition to nipple-sparing mastectomies, Dr. Hendershott offers "flat" mastectomy scars with complex closure and Goldilocks procedures for women who elect not to undergo reconstruction.


Every woman’s experience with a breast cancer diagnosis is unique. My goal is to help women participate in shared decision-making so we can chart a treatment plan together that meets their needs and goals of care. As a breast cancer survivor, I recognize that treatments can be challenging. I work to support my patients so they can move smoothly through the process and emerge whole on the other side.

Arizona Oncology - The US Oncology Network